Methyl 2-(4-(2-oxopropyl)phenoxy)acetate → HCID 14391988, compound

HRID 477101Notes

Reaction equation

HRID 477101 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[S:4][CH:5]=[C:6]([CH:8]2[O:13][CH2:12][CH2:11][NH:10][CH2:9]2)[N:7]=1.[C:16]([CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29](=O)[CH3:30])=[CH:24][CH:23]=1)([O:18][CH3:19])=[O:17]>>[C:16]([CH2:20][O:21][C:22]1[CH:23]=[CH:24][C:25]([CH2:28][CH:29]([N:10]2[CH2:11][CH2:12][O:13][CH:8]([C:6]3[N:7]=[C:3]([C:2]([F:14])([F:1])[F:15])[S:4][CH:5]=3)[CH2:9]2)[CH3:30])=[CH:26][CH:27]=1)([O:18][CH3:19])=[O:17]

Participants

3

Reactant 2

HCID 13851156Methyl 2-(4-(2-oxopropyl)phenoxy)acetateHCID 199742652-(2-Trifluoromethyl-thiazol-4-yl)morpholine

Product 1

HCID 14391988HCID 14391988, compound

Procedure

Prepared analogously to Example 13 by reaction of 2-(2-trifluoromethyl-thiazol-4-yl)morpholine with 1-(4-carbomethoxymethoxyphenyl)propan-2-one followed by purification of the base on a silica gel column using toluene/ethyl acetate=8:2 as eluant.

Workup

  1. customfollowed by purification of the base on a silica gel column

Sources & evidence

ORD record
ord-f5f501af559f43b89c657b3507e5ac53
Source dataset
uspto-grants-1989_12
Patent number
US04886814

Reaction notes

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