Acetic acid, 2-oxo-, methyl ester → Methyl 3-[2-(4-carbomethoxyphenyl)-1-methylethyl]-5-(2-trifluoromethyl-thiazol-4-yl)-2-oxazolidine carboxylate

HRID 477102Notes

Reaction equation

HRID 477102 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH:14][CH2:15][CH:16]([OH:26])[C:17]2[N:18]=[C:19]([C:22]([F:25])([F:24])[F:23])[S:20][CH:21]=2)[CH3:13])=[CH:7][CH:6]=1)([O:3][CH3:4])=[O:2].[C:27]([O:31][CH3:32])(=[O:30])[CH:28]=O>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH:12]([N:14]2[CH2:15][CH:16]([C:17]3[N:18]=[C:19]([C:22]([F:24])([F:25])[F:23])[S:20][CH:21]=3)[O:26][CH:28]2[C:27]([O:31][CH3:32])=[O:30])[CH3:13])=[CH:9][CH:10]=1)([O:3][CH3:4])=[O:2]

Participants

3

Reactant 2

HCID 70205Acetic acid, 2-oxo-, methyl esterHCID 19974173N-[2-(4-Carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

Product 1

HCID 19974308Methyl 3-[2-(4-carbomethoxyphenyl)-1-methylethyl]-5-(2-trifluoromethyl-thiazol-4-yl)-2-oxazolidine carboxylate

Procedure

Prepared analogously to Example 18 by reaction of N-[2-(4-carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine with methyl glyoxylate.

Sources & evidence

ORD record
ord-f8599ee95de740f29d6d531182f46c3a
Source dataset
uspto-grants-1989_12
Patent number
US04886814

Reaction notes

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