HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 10978660, compound → N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 10978660 | HCID 10978660 | — |
| Reactant | Methyl 2-[4-(2-aminopropyl)phenoxy]acetate | HCID 14372867 | — |
| Product | N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine | HCID 14347763 | — |
Reaction Steps
Prepared analogously to Example 3 by reaction of 2-(4-carbomethoxymethoxyphenyl)-1-methyl-ethanamine with 2-trifluoromethyl-4-bromoacetyl-thiazole followed by reduction and purification of the base on a silica gel column with methylene chloride/methanol=20:1 as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886814 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-7eb468a6ba7e41268ec46ed7fe310958 |
| Source note | uspto-grants-1989_12 |