Methyl 4-(2-aminopropyl)benzoate → HCID 19380205, compound

HRID 477105Notes

Reaction equation

HRID 477105 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH2:14])[CH3:13])=[CH:7][CH:6]=1)([O:3][CH3:4])=[O:2].Br[CH2:16][C:17]([C:19]1[N:20]=[CH:21][S:22][CH:23]=1)=[O:18]>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH:14][CH2:16][CH:17]([OH:18])[C:19]2[N:20]=[CH:21][S:22][CH:23]=2)[CH3:13])=[CH:7][CH:6]=1)([O:3][CH3:4])=[O:2]

Participants

3

Reactant 2

HCID 15034329Methyl 4-(2-aminopropyl)benzoateHCID 199741722-Bromo-1-(1,3-thiazol-4-yl)ethan-1-one

Product 1

HCID 19380205HCID 19380205, compound

Procedure

Prepared analogously to Example 3 by reaction of 2-(4-carbomethoxyphenyl)-1-methylethylamine with 4-bromoacetyl-thiazole, followed by reduction and purification of the base on a silica gel plate using ethyl acetate/methanol=8:2 as eluant.

Workup

  1. customfollowed by reduction and purification of the base on a silica gel plate

Sources & evidence

ORD record
ord-26e10c0d00bf4e6d90860cc1f78019fc
Source dataset
uspto-grants-1989_12
Patent number
US04886814

Reaction notes

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