HCID 19974199, compound → HCID 53770609, compound

HRID 477120Notes

Reaction equation

HRID 477120 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH:7]2[O:12][CH2:11][CH2:10][NH:9][CH2:8]2)[N:6]=1.[C:13]([CH:17]=[C:18]([C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27](=O)[CH3:28])=[CH:22][CH:21]=1)[CH3:19])([O:15][CH3:16])=[O:14]>>[C:13]([CH:17]=[C:18]([C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH:27]([N:9]2[CH2:10][CH2:11][O:12][CH:7]([C:5]3[N:6]=[C:2]([CH3:1])[S:3][CH:4]=3)[CH2:8]2)[CH3:28])=[CH:22][CH:21]=1)[CH3:19])([O:15][CH3:16])=[O:14]

Participants

3

Reactant 2

HCID 19974199HCID 19974199, compoundHCID 545480031-[4-(2-Carbomethoxy-1-methylethenyl)phenyl]propan-2-one

Product 1

HCID 53770609HCID 53770609, compound

Procedure

Prepared analogously to Example 13 by reaction of 2-(2-methyl-thiazol-4-yl)morpholine with 1-[4-(2-carbomethoxy-1-methyl-ethenyl)phenyl]propan-2-one followed by purification of the base on a silica gel column using chloroform/methanol/ammonia=9:1:0.1 as eluant.

Workup

  1. customfollowed by purification of the base on a silica gel column

Sources & evidence

ORD record
ord-4773797ea8d0401daf40e0787c3ad443
Source dataset
uspto-grants-1989_12
Patent number
US04886814

Reaction notes

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