4-Hydroxyphenylacetone → HCID 19974251, compound

HRID 477127Notes

Reaction equation

HRID 477127 reaction equation
[OH:1][CH:2]([C:5]1[N:6]=[C:7]([CH3:10])[S:8][CH:9]=1)[CH2:3][NH2:4].[OH:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19](=O)[CH3:20])=[CH:14][CH:13]=1>>[OH:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH:19]([NH:4][CH2:3][CH:2]([OH:1])[C:5]2[N:6]=[C:7]([CH3:10])[S:8][CH:9]=2)[CH3:20])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 70192744-HydroxyphenylacetoneHCID 167684962-Amino-1-(2-methyl-1,3-thiazol-4-yl)ethanol

Product 1

HCID 19974251HCID 19974251, compound

Procedure

Prepared by analogy to Example 13 by reaction of 2-hydroxy-2-(2-methyl-thiazol-4-yl)ethanamine with 4-hydroxyphenyl-propan-2-one followed by purification of the base on a silica gel column using chloroform/methanol/ammonia=9:1:1 as eluant.

Workup

  1. customfollowed by purification of the base on a silica gel column

Sources & evidence

ORD record
ord-aa5d99c6ce6643dea223d545e881df64
Source dataset
uspto-grants-1989_12
Patent number
US04886814

Reaction notes

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