1-(p-Methoxyphenyl)-2-propanone → N-[2-(4-Methoxyphenyl)-1-methylethyl]-2-(2-trifluoromethylthiazol-4-yl)morpholine

HRID 477128Notes

Reaction equation

HRID 477128 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[S:4][CH:5]=[C:6]([CH:8]2[O:13][CH2:12][CH2:11][NH:10][CH2:9]2)[N:7]=1.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25](=O)[CH3:26])=[CH:20][CH:19]=1>>[CH3:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][CH:25]([N:10]2[CH2:11][CH2:12][O:13][CH:8]([C:6]3[N:7]=[C:3]([C:2]([F:14])([F:1])[F:15])[S:4][CH:5]=3)[CH2:9]2)[CH3:26])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 312311-(p-Methoxyphenyl)-2-propanoneHCID 199742652-(2-Trifluoromethyl-thiazol-4-yl)morpholine

Product 1

HCID 19974318N-[2-(4-Methoxyphenyl)-1-methylethyl]-2-(2-trifluoromethylthiazol-4-yl)morpholine

Procedure

Prepared by analogy to Example 13 by reaction of 2-(2-trifluoromethyl-thiazol-4-yl)morpholine with 4-methoxyphenyl-propan-2-one followed by purification of the base on a silica gel column using chloroform/ethyl acetate=9:1 as eluant.

Workup

  1. customfollowed by purification of the base on a silica gel column

Sources & evidence

ORD record
ord-bede559238d54f6e983593c9eab6bf78
Source dataset
uspto-grants-1989_12
Patent number
US04886814

Reaction notes

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