Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium cyanoborohydride → N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | Methyl 2-(4-(2-oxopropyl)phenoxy)acetate | HCID 13851156 | — |
| 반응물 | 4-Thiazolemethanol, alpha-(aminomethyl)-2-(trifluoromethyl)- | HCID 14076239 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine | HCID 14347763 | — |
반응 단계
Prepared by analogy to Example 13 by reaction of 2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine with 1-(4-carbomethoxymethoxyphenyl)propan-2-one and sodium cyanoborohydride in methanol=(reaction time: 5 hours) followed by purification on a silica gel column using methylene chloride/methanol 20:1. This results in an approximately 50:50 diastereomer mixture of the base. This is recrystallised from a mixture of ether/ethyl acetate=65:10, and twice more from ethyl acetate. This results in diastereomer A in 98-99% purity.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04886814 |
| 출처 데이터셋 | uspto-grants-1989_12 |
| ORD ID | ord-09d028cdb07d40519cf283a953966795 |
| 출처 메모 | uspto-grants-1989_12 |