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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 477141Generated: October 29, 2026

1-(4-(2-Hydroxyethoxy)phenyl)propan-2-one → N-[2-(4-(2-Hydroxyethoxy)phenyl)-1-methylethyl]-2-hydroxy-2-(2-methyl-thiazol-4-yl)ethanamine

https://huagongshe.com/reaction/477141

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-(2-Hydroxyethoxy)phenyl)propan-2-oneHCID 14578857—
Reactant2-Amino-1-(2-methyl-1,3-thiazol-4-yl)ethanolHCID 16768496—
ProductN-[2-(4-(2-Hydroxyethoxy)phenyl)-1-methylethyl]-2-hydroxy-2-(2-methyl-thiazol-4-yl)ethanamineHCID 14372870—

Reaction Steps

Prepared by analogy to Example 13 by reaction of 2-hydroxy-2-(2-methyl-thiazol-4-yl)ethanamine with 1-[4-(2-hydroxyethoxy)phenyl)propan-2-one followed by purification on a silica gel column using methylene chloride/methanol=9:1 as eluant.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04886814
Source datasetuspto-grants-1989_12
ORD IDord-19ee4799a05b4e52b2e333648b5a8840
Source noteuspto-grants-1989_12