4-Thiazolemethanol, alpha-(aminomethyl)-2-(trifluoromethyl)- → N-[2-(4-(2-Hydroxyethoxy)phenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

HRID 477143Notes

Reaction equation

HRID 477143 reaction equation
[OH:1][CH:2]([C:5]1[N:6]=[C:7]([C:10]([F:13])([F:12])[F:11])[S:8][CH:9]=1)[CH2:3][NH2:4].[OH:14][CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25](=O)[CH3:26])=[CH:20][CH:19]=1>>[OH:14][CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][CH:25]([NH:4][CH2:3][CH:2]([OH:1])[C:5]2[N:6]=[C:7]([C:10]([F:13])([F:12])[F:11])[S:8][CH:9]=2)[CH3:26])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 140762394-Thiazolemethanol, alpha-(aminomethyl)-2-(trifluoromethyl)-HCID 145788571-(4-(2-Hydroxyethoxy)phenyl)propan-2-one

Product 1

HCID 19974156N-[2-(4-(2-Hydroxyethoxy)phenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine

Procedure

Prepared by analogy to Example 13 by reaction of 2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine with 1-(4-(2-hydroxyethoxy)phenyl)propan-2-one followed by purification on a silica gel column using ethyl acetate/methanol=9:1 as eluant.

Workup

  1. customfollowed by purification on a silica gel column

Sources & evidence

ORD record
ord-fc21ab7338c34b8ebc03750eb9aed2e3
Source dataset
uspto-grants-1989_12
Patent number
US04886814

Reaction notes

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