HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Bicarbonate → HCID 19974179, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Bicarbonate | HCID 516893 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 10978660 | HCID 10978660 | — |
| Reactant | 6-(4-{2-[(2-Hydroxyethyl)amino]propyl}phenoxy)hexan-1-ol | HCID 19974139 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 19974179 | HCID 19974179 | — |
Reaction Steps
Prepared by analogy to Example 32 by reaction of N-(2-hydroxyethyl)-2-(4-(6-hydroxyhexoxy)phenyl)-1-methylethylamine with 2-trifluoromethyl-4-bromoacetyl-thiazole and potassium hydrogen carbonate in acetone at room temperature, followed by reduction with sodium borohydride in trifluoroacetic acid. The resulting crude product is purified on a silica gel column using toluene/ethyl acetate=6:4 as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886814 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-15e504059c364f26b1c9b0d0979ad467 |
| Source note | uspto-grants-1989_12 |