HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 2-(2-Trifluoromethyl-thiazol-4-yl)ethylene oxide | HCID 14372861 | — |
| Reactant | Methyl 2-[4-(2-aminopropyl)phenoxy]acetate | HCID 14372867 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine | HCID 14347763 | — |
Reaction Steps
Prepared by analogy to Example 104 by reaction of 2-(2-trifluoromethyl-thiazol-4-yl)ethylene oxide with 2-(4-carbomethoxymethoxyphenyl)-1-methylethylamine and dimethyl sulfoxide at 90° C. for 16 hours. The base is obtained by extraction by shaking with ether and purification on a silica gel column using methylene chloride/methanol 20:1 as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886814 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-0f7cc50781024ff78bed3bfeb308e48c |
| Source note | uspto-grants-1989_12 |