Trifluridine → HCID 14722799, compound

Participants

Reaction Conditions

Reaction Steps

1.00 Gram of 2'-deoxy-5-trifluoromethyluridine was dissolved in 15 ml of 1,4-dioxane. Thereto were added 2.50 g of bis-(α,α-dimethylbenzyloxy)methane and 38 mg of toluenesulfonic acid anhydride. They were heated to 60° C. and stirred for 3.5 hours. The reaction mixture was subjected to evaporation. The residue was subjected to silica gel column chromatography wherein a developing solvent of chloroform-methanol (20:1) was first used for preliminary separation and then a developing solvent of benzene-acetone (10:1) was used, to obtain 0.40 g (yield: 29.2%) of hygroscopic and amorphous 2'-deoxy-5'-O-(α,α-dimethylbenzyl)-5-trifluoromethyluridine (compound 22) and 0.28 g (yield: 20.4%) of hygroscopic and amorphous 2'-deoxy-3'-O-(α,α-dimethylbenzyl)-5-trifluoromethyluridine (compound 23).

Provenance & Evidence