Benzylamine → HCID 19086853, compound

HRID 477191Notes

Reaction equation

HRID 477191 reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14][CH2:13]3)=[O:9])[CH2:4][CH2:3]1.[CH2:21]([NH2:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(Cl)(Cl)Cl>[CH2:21]([N:28]=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14][CH2:13]3)=[O:9])[CH2:4][CH2:3]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 19086843HCID 19086843, compound

Product 1

HCID 19086853HCID 19086853, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

0.8 Gram of 6-(4-oxo-1-piperidyl)carbonyl-3,4-dihydrocarbostyril, 1.6 ml of benzylamine and 1 g of Molecular Sieve 3A (a trademark for synthetic feldspar manufactured by Linde Co., U.S.A.) were dispersed in 15 ml of chloroform and refluxed by heating for 6 hours. Molecular Sieve 3A was removed by filtration, the filtrate was concentrated, then the residue obtained was washed several times with diethyl ether, next, purified by means of a silica gel column chromatography to obtain 6-(4-benzylimino-1-piperidyl)carbonyl-3,4-dihydrocarbostyril.

Workup

  1. temperaturerefluxed
  2. temperatureby heating for 6 hours
  3. customMolecular Sieve 3A was removed by filtration
  4. concentrationthe filtrate was concentrated
  5. customthe residue obtained
  6. washwas washed several times with diethyl ether
  7. customnext, purified by means of a silica gel column chromatography

Sources & evidence

ORD record
ord-cb74b5b3a3764c7ebfbf4277bd932a2f
Source dataset
uspto-grants-1989_12
Patent number
US04886809

Reaction notes

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