HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl chloroformate → Diethyl 2-(benzyloxycarbonylamino)malonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | Propanedioic acid, 2-amino-, 1,3-diethyl ester, hydrochloride (1:1) | HCID 3084143 | — |
| Product | Diethyl 2-(benzyloxycarbonylamino)malonate | HCID 259787 | 93.2% |
Reaction Steps
Diethyl 2-aminomalonate hydrochloride (12.7 g) and benzyloxycarbonyl chloride (11.9 g) are treated in the same manner as described in Reference Example 19-(3) to give diethyl 2-(N-benzyloxycarbonylamino)malonate (17.3 g), m.p. 36.5°-37° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886894 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-51f047eaa7df4a48b69d8a1b6d805165 |
| Source note | uspto-grants-1989_12 |