Trimethylsilyl cyanide → HCID 14181182, compound

Participants

Reaction Steps

2 to 3 drops of BF3 -etherate solution are added to 0.1 mol of methyl 5-oxo-5,6,7,8-tetrahydro-naphth-2-yl-oxyacetate and 0.15 mol of trimethylsilyl cyanide, and the mixture is stirred at room temperature for 30 minutes and then at 50° C. for 1 hour. 250 ml of a saturated methanolic hydrogen chloride solution are added to this solution at room temperature and the mixture is stirred for 1 hour. Some of the product precipitates out and is filtered off. A further batch is obtained by evaporating the motor liquor, taking up the residue in CH2Cl2, extracting the mixture twice by shaking with 0.5N NaOH, drying the extract over Na2SO4 and evaporating it and recrystallizing the residue from a little methanol or diisopropyl ether.

Provenance & Evidence