Dimethyl Disulfide → 2-Fluoro-6-(methylsulfanyl)aniline

HRID 477266Notes

Reaction equation

C(OC([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[F:15])=O)(C)(C)C.[CH3:16][S:17]SC>>[F:15][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]([S:17][CH3:16])[C:9]=1[NH2:8]

Participants

Reactant 2

HCID 12232Dimethyl Disulfide

HCID 4935500Tert-butyl 2-fluorophenylcarbamate

Product 1

HCID 117688252-Fluoro-6-(methylsulfanyl)aniline

Procedure

This material was prepared for N-t-butoxycarbonyl-2-fluoroaniline and dimethyl disulfide following the general procedure outlined in Example 102. IR and 1H NMR spectra of the product were consistent with the assigned structure.

Sources & evidence

ORD record: ord-98ae86c9e0ee48de98980381426fc8d8
Source dataset: uspto-grants-1989_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04886883

Reaction notes

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