Methanol → HCID 19995392, compound

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Reaction Steps

8.1 g (0.0209 mole) of the acid obtained in Example 5, 100 ml of methanol and 0.6 ml (0.0105 mole) of concentrated sulfuric acid are introduced in a balloon-flask, then heated by retort for 8 hours. After dry evaporation, water is added, neutralization is effected with sodium bicarbonate, followed with extraction with dichloromethane. After drying the organic phase on magnesium sulfate, the resulting solid is evaporated and then recrystallized in acetonitrile. Yield: 7.6 g (90.5%), fusion temperature: (224°-225° C.). RF: 0.5 [Merck silica plaques, the eluent being a mixture of ether-hexane (50:50)

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