HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → HCID 19980018, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 2-chloro-3-methylbutanoic acid | HCID 313493 | — |
| Reactant | HCID 19809977 | HCID 19809977 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 19980018 | HCID 19980018 | — |
Reaction Steps
A mixture of 5.3 g of p-[p-(4-cyano-4-octylcyclohexyl)phenyl]phenol (obtainable by alkaline ether splitting from r-1-cyano-cis-4-(4'-propyloxybiphenyl-4-yl)-1-octylcyclohexane with potassium tert-butylate in NMP at 180°), 1.9 g of optically active 2-chloro-3-methylbutyric acid and 170 g of DMAP are suspended in 40 ml of CH2Cl2. 3.1 g of DCC in 5 ml of CH2Cl2 are then added dropwise at 0° and stirring is carried out for 12 hours at room temperature. After separating off the dicyclohexylurea and the usual working up, optically active 4'-(4-cyano-4-octylcyclohexyl)-biphenyl-4-yl 2-chloro-3-methylbutyrate is obtained, K 81 SA 138 I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886620 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-1dcabaafe62b4426b58fbdd313185409 |
| Source note | uspto-grants-1989_12 |