HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl [(4-Chlorophenyl)thio]acetate → Diethyl 5-(4-chlorophenylthio)-2-dimethylamino-2,4-hexadienedioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl [(4-Chlorophenyl)thio]acetate | HCID 257604 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | N-(dimethylamino-3-ethoxycarbonylpropenylidene)-N-methylmethanaminium tetrafluoroborate | HCID 86743575 | — |
| Reactant | Diethyl 2-dimethylamino-5-phenylthio-2,4-hexadienedioate | HCID 86743580 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Diethyl 5-(4-chlorophenylthio)-2-dimethylamino-2,4-hexadienedioate | HCID 53649134 | 99.3% |
Reaction Steps
The procedure is as in Example 2 for the preparation of diethyl 2-dimethylamino-5-phenylthio-2,4-hexadienedioate, starting with N-(3-dimethylamino-3-ethoxycarbonylpropenylidene)-N-methylmethanaminium tetrafluoroborate (14.3 g), a 2M ethanolic solution of sodium ethylate (25 cc) and ethyl (4-chlorophenylthio)acetate (11.5 g) in ethanol (100 cc). Diethyl 5-(4-chlorophenylthio)-2-dimethylamino-2,4-hexadienedioate (19 g) is thereby obtained, and is used in the crude state in the subsequent phases.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886835 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-1c3675ddc668401cbdb83c0864a75dbe |
| Source note | uspto-grants-1989_12 |