HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Thioglycolate → Ethyl (4-trifluoromethylbenzylthio)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Thioglycolate | HCID 12185 | — |
| Reactant | p-Trifluoromethylbenzyl chloride | HCID 123096 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | Ethyl (4-methylbenzylthio)acetate | HCID 4107274 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl (4-trifluoromethylbenzylthio)acetate | HCID 54499618 | — |
Reaction Steps
The procedure is as in Example 29 for the preparation of ethyl (4-methylbenzylthio)acetate, starting with 1-chloromethyl-4-trifluoromethylbenzene (9.8 g), a 2M ethanolic solution of sodium ethylate (25 cc) and ethyl 2-mercaptoacetate (6.1 g) in ethanol (120 cc). Ethyl (4-trifluoromethylbenzylthio)acetate (12.2 g) is thereby obtained, and is used in the crude state in the subsequent syntheses.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886835 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-077fc35a9ac04ff8a614f717e09a5f52 |
| Source note | uspto-grants-1989_12 |