Ethanol → HCID 54557924, compound

Participants

Reaction Steps

The procedure is as in Example 4 for the preparation of ethyl 6-phenyl-6-oxo-5-methylthio-2-dimethylamino-2,4-hexadienoate, starting with N-(3-dimethylamino-3-ethoxycarbonylpropenylidene)-N-methylmethanaminium tetrafluoroborate (8 g), a 2M ethanolic solution of sodium ethylate (14 cc) and ethyl 1-(3-biphenylyl)acetate (6.7 g) in ethanol (30 cc). After purification by chromatography on a silica column with dichloromethane as eluent, diethyl 2-dimethylamino-5-(3-biphenylyl)-2,4-hexadienedioate (4.2 g) is obtained in the form of a yellow oil, and is used in the curde state in the subsequent syntheses.

Provenance & Evidence