Ethyl Thioglycolate → HCID 54250288, compound

Participants

Reaction Steps

The procedure is as in Example 29 for the preparation of ethyl (4-methylbenzylthio)acetate, starting with 2-bromomethylnaphthalene (20 g), sodium hydride (5.1 g) in a 50% strength dispersion in liquid paraffin and ethyl 2-mercaptoacetate (10.9 g) in tetrahydrofuran (200 cc). After purification by chromatography on a silica column with a mixture of cyclohexane and ethyl acetate (80:20 by volume) as eluent, ethyl (2-naphthylmethylthio)acetate (12 g) is obtained, and is used in the crude state in the subsequent syntheses.

Provenance & Evidence