Ammonium Chloride → HCID 19835545, compound

Participants

Reaction Steps

7.5 g of zinc powder and a solution of 0.3 g of ammonium chloride in 1.5 ml of water are added to 15 ml to 96° strength alcohol. The mixture is heated to the reflux temperature, with stirring, and 0.015 mol (3.4 g) of the 1-(2'-amino-5'-nitrophenoxy)-3-aminopropan-2-ol prepared according to Example 5 is then added gradually so as to maintain the reflux without external heating. When the addition has ended, the reflux is maintained for 5 minutes and the boiling reaction medium is then filtered into 4.6 ml of iced hydrochloric acid (specific gravity=1.18). The expected product crystallises in the form of the trihydrochloride. The product is filtered off, washed with alcohol and dried in vacuo. It melts with decomposition at 216°-218° C.

Provenance & Evidence