HCID 19835547, compound → HCID 19835523, compound

Participants

Reaction Steps

0.02 mol (5.3 g) of the 1-(2'-amino-4'-nitrophenoxy)-3-aminopropan-2-ol monohydrochloride prepared according to Example 4 is introduced into 50 ml of 96° strength alcohol and 0.2 g of 10% strength palladium-on-charcoal. The mixture is heated at 85° C. for one hour under 35 bars of hydrogen. After cooling, it is filtered to remove the catalyst, the filtrate being collected in 20 ml of iced ethanol saturated with hydrogen chloride. The expected product precipitates in the form of the trihydrochloride. After recrystallisation of this trihydrochloride from an ethanol/water mixture, it melts with decomposition at 236°-238° C.

Provenance & Evidence