1H-1,2,4-Triazole → HCID 14330161, compound

Participants

Reaction Steps

37 g (0.138 mol) of 2-(4-chlorophenyl)-2-(tetrahydro-2H-pyran-2-yl-oxymethyl)-oxirane are added to a mixture of 22.4 g (0.32 mol) of 1,2,4-triazole, 5 g (0.04 mol) of potassium tert.-butylate and 300 ml of dimethylformamide at room temperature, while stirring. After the addition has ended, the reaction mixture is stirred at 80° C. for 12 hours and is then concentrated by stripping off the solvent under reduced pressure. Water is added to the residue which remains, the resulting mixture is extracted three times with methylene chloride and the combined organic phases are dried over magnesium sulphate and concentrated by stripping off the solvent under reduced pressure. The product thus obtained is purified chromatographically on silica gel with methylene chloride/ethyl acetate =4:1 as the mobile phase. 33.5 g (72% of theory) of 2-(4-chlorophenyl)-1-[(tetrahydro-2H-pyran-2-yl)-oxy]-3-(1,2,4-triazol-1-yl)-propan-2-ol are obtained in this manner in the form of pale yellow crystals of melting point 70° C.

Provenance & Evidence