Ammonia → Mitoxantrone

Participants

Reaction Steps

A mixture of 30.0 g of 1,4-dihydroxy-5,8-bis-[[2-(2-hydroxyethylamino)ethyl]amino]-anthraquinone dihydrochloride (U.S. Pat. No. 4,197,249) and 300 ml of methanol was chilled in an ice bath in a Dewar flask. The mixture was saturated with ammonia gas and stirred at 0° C. for one hour with the continuous slow addition of ammonia gas. The solid was collected and washed by slurrying with five 150 ml portions of ammonia saturated methanol, giving 22.9 g of 1,4-dihydroxy-5,8-bis[[2-(2-hydroxyethylamino)ethyl]amino]anthraquinone free base as blue-black microrods, mp 175°-178° C.

Provenance & Evidence