HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-[3-(Diethylamino)Propyl]-4-Phenyl-1H-Pyrazole-1-Acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N,N-Diethyl-1,3-propanediamine | HCID 61011 | — |
| Reactant | ethyl 4-phenyl-1H-pyrazole-1-acetate | HCID 14772168 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[3-(Diethylamino)Propyl]-4-Phenyl-1H-Pyrazole-1-Acetamide | HCID 14772169 | 19.9% |
Reaction Steps
A solution of 13.5g (0.059 mol) of ethyl 4-phenyl-1H-pyrazole-1-acetate of example 3 and 12.6 mL (0.08 mol) of 3-(diethylamino)propanamine in 130 mL of DMF was stirred at 100° C. for 4hr. The reaction was poured into water, extracted into methlene chloride, and stripped. The residue was triturated in ether and the resulting solid was recrystallized from ether-hexane to yield 3.70g of product, mp 55°-57° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04888352 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-7f93ab8813164db185911a1c01c218ee |
| Source note | uspto-grants-1989_12 |