Phenacyl bromide → HCID 178424201, compound

Participants

Reaction Steps

To a solution of 6.1 g (0.0455 mole) of 2-methylbenzamidine in 25 ml of chloroform 3.6 g (0.018 mole) of α-bromoacetophenone were added and the resulting mixture was refluxed for four hours. After cooling and adding 50 ml of chloroform the reaction mixture was first washed with diluted ammonia and then with water and subsequently dried over sodium sulfate. The sodium sulfate was removed by filtration and the filtrate was chromatographed through silica gel by eluting with mixtures of CHCl3 /CH3COOC2H5 containing up to a maximum of 4% (in volume) of CH3COOC2H5. The fractions eluted with CH3Cl3 /CH3COOC2H5 =9/1 (v/v) were collected, the solvent was evaporated off and the residue was crystallized from diethylether/light petroleum. Yield 1.95 g (46.3%) of the title compound M.p. 145°-46° C.

Provenance & Evidence