HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → beta-Cyclobutyl-beta-oxo-alpha-methylcarbamoylpropionitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 3-Cyclobutyl-3-oxopropanenitrile | HCID 13861115 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | beta-Cyclobutyl-beta-oxo-alpha-methylcarbamoylpropionitrile | HCID 14819883 | 77.9% |
Reaction Steps
β-Cyclobutyl-β-oxopropionitrile (2.25 g, 18.3 mmoles) [prepared in Step A]was reacted with methyl isocyanate (1.10 g, 19.2 mmoles) according to the general procedure of Example 1, Step B to yield 2.57 g of the title compound as a white solid afater recrysstallization from 50% aqueous ethanol, mp 81°-83° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04888357 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-82e788fc91f54ef6a9468b3285fe149c |
| Source note | uspto-grants-1989_12 |