Potassium Hydroxide → HCID 178524740, compound
Reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[N:10]([N:13]=[CH:14][N:15]=2)[C:11]=1[SH:12])=[O:5])C.[OH-].[K+]>>[C:4]([C:6]1[CH:7]=[N:8][C:9]2[N:10]([N:13]=[CH:14][N:15]=2)[C:11]=1[SH:12])([OH:5])=[O:3]Participants
3
Conditions
- Temperature
- 80 °C
Procedure
The product obtained in Step 2 (2.4 g) was dissolved in 50 ml of aqueous solution containing 1.0 g potassium hydroxide, the solution was heated at 80° C. for one hour, the insoluble matters were filtered off, and the clear, faint yellow filtrate was washed with 30 ml ethyl acetate. The pH of the aqueous layer was lowered to 1.0 with concentrated hydrochloric acid, and the crystals thus formed were collected by filtration, affording 2.0 g of the objective compound as colorless crystals.
Workup
- filtrationthe insoluble matters were filtered off
- washthe clear, faint yellow filtrate was washed with 30 ml ethyl acetate
- customthe crystals thus formed
- filtrationwere collected by filtration
Sources & evidence
- ORD record
- ord-ab23c87178ac40028c5bd3f95dc6f9c3
- Source dataset
- uspto-grants-1989_12
- Patent number
- US04888332
Reaction notes
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