HCID 19989233, compound → HCID 19989223, compound

Participants

Reaction Steps

To a suspension of the product obtained in Step 2 (3.5 g) was dropwise added 8.6 ml of 1M sodium ethoxide ethanol solution with vigorous stirring under ice cooling over a period of ten minutes. The mixture was stirred at room temperature for one hour, and the resulting yellow solution was concentrated under reduced pressure. The remaining yellow oil was shaken with 100 ml of chloroform and 50 ml of water. The chloroform layer was separated and the aqueous layer was again extracted with 100 ml of fresh chloroform. The chloroform layers were joined and washed with 100 ml of saturated sodium chloride solution and dried over anhydrous sodium sulfate. The chloroform solution was concentrated under reduced pressure, and 20 ml of n-hexane was added to the concentrate to give 1.8 g of the objective compound as faint yellow crystals.

Provenance & Evidence