反应详情

The product obtained in Step 1 (4.5 g) was added to a solution of 1.7 g potassium hydroxide in 50 ml water, and the mixture was refluxed for two hours. After cooling to room temperature, the solution was washed with 50 ml of ethyl acetate, the pH was adjusted to 1.0 with hydrochloric acid, and the formed crystals were collected by filtration, affording 3.9 g of the objective compound.

1. temperaturethe mixture was refluxed for two hours
2. washthe solution was washed with 50 ml of ethyl acetate
3. filtrationthe formed crystals were collected by filtration