反应详情

温度

50 °C

6-Methyluracil (25.0 g) was suspended in 1 liter of distilled pyridine with stirring and heated at 50° C. into solution. Phosphorus pentasulfide (12.6 g) was then added, and the mixture was refluxed for 20 hours. The solution was concentrated under reduced pressure, then the residue was refluxed with 500 ml of ethanol for one hour. Insoluble materials were removed by filtration and the filtrate was concentrated under reduced pressure. The residue was recrystallized from ethanol, affording 5.5 g of the objective compound as colorless crystals.

1. temperaturethe mixture was refluxed for 20 hours
2. concentrationThe solution was concentrated under reduced pressure
3. temperaturethe residue was refluxed with 500 ml of ethanol for one hour
4. customInsoluble materials were removed by filtration
5. concentrationthe filtrate was concentrated under reduced pressure
6. customThe residue was recrystallized from ethanol