Carbon Dioxide → HCID 86743610, compound

Participants

Reaction Steps

A solution of mitomycin A (100 mg or 0.286 mmole) in 4 ml of diethylene glycol monoethyl ether was stirred at room temperature and under nitrogen for 45 minutes with 480 mg of a 1.6% solution of KOH in diethylene glycol monoethyl ether. The reaction mixture was decomposed with excess dry ice while immersing the flask into a water bath at room temperature. It was then isolated on a silica gel column using CHCl3 -MeOH 9:1 as solvent. Final purification was achieved by preparative thin layer chromatography on silica gel with a mixture of CHCl3 -MeOH 9:1. This procedure resulted in 80 mg (62%) of the title compound, having a melting point of 140°-143° C. (decomposition) and providing the following analysis:

Provenance & Evidence