Carbon Dioxide → HCID 19904324, compound

Participants

Reaction Steps

A solution of mitomycin A (100 mg or 0.286 mmole) in 4 ml of tetrahydrofurfuryl alcohol was stirred at room temperature and under nitrogen for 45 minutes with 480 mg of a 1.6% solution of KOH in tetrahydrofurfuryl alcohol. The reaction mixture was decomposed with excess dry ice while immersing the flask into a water bath at room temperature. The product was chromatographed on a silica gel column using CHCl3 -MeOH 9.5:0.5 as solvent. Further purification of the product was done by preparative thin layer chromatography (silica gel, CHCl3 -MeOH 9.5:0.5). This procedure resulted in 72 mg (60%) of the desired product having a melting point of 128°-133° C. (decomposition) and providing the following analysis:

Provenance & Evidence