Carbon Dioxide → HCID 19835790, compound

Participants

Reaction Steps

A solution of mitomycin A (100 mg or 0.286 mmole) in 4 ml of tetrahydropyran-2-methanol was stirred at room temperature and under nitrogen for 45 minutes with 240 mg of a 1.6% solution of KOH in tetrahydropyran-2-methanol. The reaction mixture was decomposed with excess dry ice while immersing the flask into a water bath at room temperature. The reaction mixture was chromatographed on a silica gel column using CHCl3 and then CHCl3 -MeOH 9.5:0.5. The product was further purified by preparative thin layer chromatography (silica gel, CHCl3 -MeOH 9.5:0.5). Thus, there was obtained 57 mg (46%) of the desired product having a melting point of 135°-138° C. (decomposition) and providing the following analysis:

Provenance & Evidence