Carbon Dioxide → HCID 86743612, compound

Participants

Reaction Steps

A solution of mitomycin A (100 mg or 0.286 mmole) in 4 ml of glycidol was stirred at room temperature and under nitrogen for 45 minutes with 500 mg of a 1.6% solution of KOH in glycidol. The reaction mixture was decomposed with excess dry ice while immersing the flask into a water bath at room temperature. The crude reaction product was chromatographed on a silica gel column using first CHCl3 -MeOH 9.5:0.5, which elutes glycidol and pink by-products, and then CHCl3 -MeOH 9:1, which elutes the product. The product was further purified by preparative thin layer chromatography on silica gel with a mixture of CHCl3 and methanol 9:1 as the solvent. Thus, there was obtained 71 mg (33%) of the desired product, which gave indefinite decomposition on heating and provided the following compound analysis:

Provenance & Evidence