1-Hydroxybenzotriazole → HCID 178418300, compound

Participants

Reaction Steps

Competition experiments demonstrate that under the reaction conditions followed the BOP Reagent functions to form the symmetrical acid anhydride within about one minute. During the remaining ten minutes of preactivation mixing a portion of the symmetrical anhydride is converted by HOBt liberated from the BOP Reagent to form an intermediate hydroxybenzotriazole active ester. This active ester intermediate then couples with the available reactive functionalities on the synthesis resin or the coupled amino acid in the peptide chain.

Provenance & Evidence