HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(2-chloroethyl)-1-methyl-2,4(1H,3H)-quinazolinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(2-hydroxyethyl)-1-methyl-2,4(1H,3H)-quinazolinedione | HCID 14989892 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-(2-chloroethyl)-1-methyl-2,4(1H,3H)-quinazolinedione | HCID 14989893 | 95% |
Reaction Steps
A mixture of 4.5 parts of 3-(2-hydroxyethyl)-1-methyl-2,4(1H,3H)-quinazolinedione, 8 parts of thionyl chloride and 75 parts of trichloromethane was stirred and refluxed for 5 hours. The reaction mixture was evaporated, yielding 4.5 parts (95%) of 3-(2-chloroethyl)-1-methyl-2,4(1H,3H)-quinazolinedione as a residue (intermediate 171).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04888426 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-2b68d0fbcd524debb438329d405ff965 |
| Source note | uspto-grants-1989_12 |