1-(2-furanylmethyl)-N-[1-(2-isothiocyanatoethyl)-4-piperidinyl]-1H-benzimidazol-2-amine → HCID 178505783, compound

HRID 477687Notes

Reaction equation

HRID 477687 reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[F:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:15]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[N:17]=[C:16]2[NH:24][CH:25]2[CH2:30][CH2:29][N:28]([CH2:31][CH2:32]NC3N(C)C4C=NC=CC=4N=3)[CH2:27][CH2:26]2)=[CH:10][CH:9]=1.O1C=CC=C1C[N:50]1C2C=CC=C[C:53]=2[N:52]=[C:51]1[NH:59][CH:60]1[CH2:65][CH2:64][N:63](CCN=C=S)[CH2:62][CH2:61]1>>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[F:7][C:8]1[CH:9]=[CH:10][C:11]([CH2:14][N:15]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[N:17]=[C:16]2[NH:24][CH:25]2[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][CH2:53][NH:52][C:51]3[NH:59][C:60]4[CH:61]=[CH:62][N:63]=[CH:64][C:65]=4[N:50]=3)[CH2:27][CH2:26]2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 148353051-(2-furanylmethyl)-N-[1-(2-isothiocyanatoethyl)-4-piperidinyl]-1H-benzimidazol-2-amineHCID 131715260N-[2-[4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]-3-methyl-3H-imidazo[4,5-c]pyridin-2-amine ethanedioate

Product 1

HCID 178505783HCID 178505783, compound

Procedure

N-[2-[4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]-3-methyl-3H-imidazo[4,5-c]pyridin-2-amine ethanedioate(1:3) monohydrate; mp. 242.3° C. (compound 123).

Sources & evidence

ORD record
ord-4402948bf5a9467d8ad3d0ee05c85902
Source dataset
uspto-grants-1989_12
Patent number
US04888426

Reaction notes

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