Benzoyl chloride → HCID 19872301, compound

Participants

Reaction Steps

A suspension of N-(2,6-difluorophenyl)-5-methyl-1-(2-pyrimidinyl)-1,2,4-triazole-3-sulphonamide (1.5 g) (Compound A54) and anhydrous potassium carbonate (0.59 g) in dry acetone (50 ml) was heated under reflux for 30 minutes. A solution of benzoyl chloride (0.6 g) in acetone (50 ml) was added, and the mixture was refluxed for a further 2 hours. The mixture was then allowed to stand at 25° C. for 18 hours, after which it was warmed, filtered and evaporated. The solid produced was recrystallised from acetonitrile to give 1.05 g of the desired product, mp 218°-221° C.

Provenance & Evidence