Acetyl chloride → 1-Acetyl-5-amino-3-benzylthio-1,2,4-triazole

Participants

Reaction Steps

Acetyl chloride (12.57 g) in methylene chloride (30 ml) was added to the product of stage (a) (30 g) and triethylamine (25 ml) in methylene chloride (300 ml) at 0° C., and the mixture was stirred at room temperature for 30 minutes. It was then treated with 1N sodium hydroxide (160 ml) and extracted with methylene chloride. The product, after drying, was recrystallised from ethyl acetate to give 33 g of the desired product, mp 146° C.

Provenance & Evidence