2,6-Dichloroaniline → HCID 178482477, compound

Participants

Reaction Conditions

Reaction Steps

The product of stage (b) (4.34 g) was added with stirring to 2,6-dichloroaniline (3.24 g) in pyridine (30 ml), and the mixture was stirred at 50° C. for 18 hours. After removal of the pyridine, the residue was dissolved in sodium hydroxide solution (50 ml) and was extracted with ethyl acetate (50 ml). The aqueous phase was acidified to pH=4-5 with 2N hydrochloric acid, cooled, and the product was filtered off, washed with a little water, and dried to give 3.49 g of the desired product, mp 285°-287° C.

Provenance & Evidence