1,4-Dioxane → HCID 14276851, compound

Participants

Reaction Conditions

Reaction Steps

The product of stage (a) (31 g) was mixed with dioxan (200 ml) and 96% sodium borohydride (19.6 g) at room temperature, and acetic acid (30 ml) was added with vigorous stirring. The mixture was stirred at 100° C. for 2 hours, after which the solvents were removed and the mixture was added carefully to water. The product was then extracted with ethyl acetate and chromatographed on silica gel to give 21.4 g of the desired product.

Provenance & Evidence