HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 47774Generated: October 29, 2026
Ethanol → ethyl (2R)-2-amino-5-[(benzoyloxy)carbonyl]aminopentanoate hydrochloride
https://huagongshe.com/reaction/47774
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2R)-2-amino-5-[(benzyloxy)carbonyl]aminopentanoic acid hydrochloride | HCID 69885572 | — |
| Product | ethyl (2R)-2-amino-5-[(benzoyloxy)carbonyl]aminopentanoate hydrochloride | HCID 86584446 | — |
Reaction Steps
A solution of 12.5 g of (2R)-2-amino-5-[(benzyloxy)carbonyl]aminopentanoic acid hydrochloride in 200 cm3 of ethanol is cooled to a temperature in the region of −20° C. 6.5 cm3 of thionyl chloride are added dropwise and the mixture is then stirred at a temperature in the region of 20° C. for 18 hours. The reaction medium is concentrated under reduced pressure (1 kPa) at a temperature in the region of 40° C. to give 13 g of ethyl (2R)-2-amino-5-[(benzoyloxy)carbonyl]aminopentanoate hydrochloride [mass spectrum: DCI m/z=295 MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06699895B2 |
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| Source dataset | uspto-grants-2004_03 |
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| ORD ID | ord-9ced4970efc84c1bb4b2ae7a1c24e74f |
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| Source note | uspto-grants-2004_03 |
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