2-Chloropyrimidine → HCID 19872288, compound

HRID 477746Notes

Reaction equation

HRID 477746 reaction equation
[CH2:1]([S:8][C:9]1[N:13]=[C:12]([S:14][CH3:15])[NH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:17]1[N:22]=[CH:21][CH:20]=[CH:19][N:18]=1>>[CH2:1]([S:8][C:9]1[N:13]=[C:12]([S:14][CH3:15])[N:11]([C:17]2[N:22]=[CH:21][CH:20]=[CH:19][N:18]=2)[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 744042-ChloropyrimidineHCID 178503580HCID 178503580, compound

Product 1

HCID 19872288HCID 19872288, compound

Procedure

The product of stage (a) (50 g) was treated with 2-chloropyrimidine (24.4 g) in a method analogous to that of Example F, to give, after chromatographic separation of two products, 23.6 g of the desired product.

Workup

  1. customto give
  2. customafter chromatographic separation of two products, 23.6 g of the desired product

Sources & evidence

ORD record
ord-46190c8f1da14c1a8cb9abdc2e881651
Source dataset
uspto-grants-1989_12
Patent number
US04889553

Reaction notes

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