Chloroform → HCID 14626271, compound

Participants

Reaction Steps

A solution of 5 g of 2-(dimethyl-t-butylsilyloxy)-6,11-dihydrodibenz[b,e]oxepin-11-one in 50 ml of methanol is cooled to 0° C. After adding 2 g of sodium borohydride and the mixture is stirred for 1 hour, 300 ml of chloroform is added and the mixture is washed with water and a saturated saline solution, followed by drying over magnesium sulfate. The solvent is distilled off under reduced pressure and the residue is subjected to silica-gel chromatography and eluted with toluene to give 4.1 g of 2-(dimethyl-t-butylsilyloxy)-6,11-dihydrodibenz[b,e]oxepin-11-ol (oil). Mass spectrum m/z: 342(M+).

Provenance & Evidence