Sodium Hydroxide → Benzoic Acid

Participants

Reaction Steps

To a solution of 13 g of ethyl 3-fluoro-2-[(3-fluorophenyloxy)methyl]benzoate in 100 ml of ethanol is added 50 ml of 5% aqueous solution of sodium hydroxide and the mixture is refluxed with heating for 1 hour. After the solvent is distilled off under reduced pressure, 300 ml of water is added and then 10% hydrochloric acid is added to make the mixture acidic. The precipitated crystals are collected by filtration and dried to give 11 g of 3-fluoro-2-[3-fluorophenyloxy)methyl]benzoic acid. Mass spectrum m/z: 264(M+).

Provenance & Evidence