反应详情

To a solution of 15 g of ethyl 5-fluoro-2-[(3-fluorophenyloxy)methyl]benzoate in 200 ml of ethanol is added 100 ml of 5% aqueous sodium hydroxide and the mixture is refluxed with heating for 1 hour. After cooling, the solvent is distilled off under reduced pressure and the residue is added with 300 ml of water and then with 10% hydrochloric acid to make the mixture acidic. The precipitated crystals are collected by filtration and dried to give 12 g of 5-fluoro-[(3-fluorophenyloxy)methyl]benzoic acid. Mass spectrum m/z: 264(M+).

1. temperaturethe mixture is refluxed
2. temperaturewith heating for 1 hour
3. temperatureAfter cooling
4. distillationthe solvent is distilled off under reduced pressure
5. additionthe residue is added with 300 ml of water
6. filtrationThe precipitated crystals are collected by filtration
7. customdried